Effects of a supplement containing chromium and magnesium on morphometric measurements, resting glucose, insulin concentrations and insulin sensitivity in laminitic obese horses.
Authors: Chameroy K A, Frank N, Elliott S B, Boston R C
Journal: Equine veterinary journal
Summary
# Editorial Summary Obesity-associated insulin resistance represents a critical metabolic driver of laminitis in equids, prompting investigation into whether supplemental chromium and magnesium might ameliorate this pathophysiology. Over 16 weeks, researchers administered a nutraceutical blend (5 mg chromium as yeast and 8.8 g magnesium as oxide/proteinate daily) to six previously laminitic obese horses (body condition score ≥7/9), whilst six matched controls received placebo, with insulin sensitivity assessed via insulin-modified frequently sampled intravenous glucose tolerance testing and minimal model analysis at baseline, 8 and 16 weeks. Hyperinsulinaemia (>30 µu/ml) was prevalent in 12 of 14 horses at outset, yet the supplement failed to improve insulin sensitivity (mean baseline 0.64 ± 0.62 × 10⁻⁴ l/min/µu), morphometric measurements, resting glucose or resting insulin concentrations, with resting insulin actually increasing significantly over time across both groups (P = 0.018). Whilst the null findings suggest that this particular formulation and dosage do not represent an effective intervention for metabolically compromised obese horses, the persistence of severe hyperinsulinaemia in this cohort underscores the pressing need for further research into both supplement composition and practical management strategies—particularly regarding weight loss—to address insulin dysregulation in this high-risk population.
Read the full abstract on PubMed
Practical Takeaways
- •Chromium and magnesium supplements alone do not improve insulin sensitivity or aid weight loss in obese laminitic horses—alternative management strategies are needed
- •Hyperinsulinaemia is highly prevalent in this population; clinicians should not rely on these supplements as a primary intervention for insulin resistance
- •Further research is required to establish effective nutraceutical or pharmacological approaches for managing insulin resistance in horses
Key Findings
- •Chromium and magnesium supplementation did not significantly improve insulin sensitivity in laminitic obese horses over 16 weeks
- •Hyperinsulinaemia (>30 µu/ml) was present in 12 of 14 horses prior to treatment
- •Resting insulin concentrations significantly increased over time in both groups (P = 0.018), suggesting supplement inefficacy
- •No changes in morphometric measurements or blood variables were observed with supplementation