Efficacy of Platelet-Rich Plasma in the Treatment of Equine Tendon and Ligament Injuries: A Systematic Review of Clinical and Experimental Studies
Authors: J. Carmona, C. López
Journal: Veterinary Sciences
Summary
# Editorial Summary: Platelet-Rich Plasma for Equine Tendon and Ligament Injuries Tendon and ligament injuries remain a significant cause of prolonged recovery and performance loss in horses, prompting ongoing investigation into regenerative therapies that might improve healing trajectories. Carmona and López conducted a systematic review of 22 clinical and experimental studies examining platelet-rich plasma (PRP) as a treatment modality, evaluating improvements in lameness, tissue healing, and return-to-competition timelines. The evidence supports PRP's therapeutic potential with a favourable safety profile; however, the review identified substantial variability across studies in preparation protocols—including platelet and leukocyte concentrations, activation methods, and application dosages—which significantly undermines protocol standardisation and reproducibility. Combination approaches pairing PRP with mesenchymal stem cells showed promise in some studies, though the authors stress that larger, methodologically rigorous trials remain essential before definitive clinical guidelines can be established. For equine professionals considering PRP treatment, the current evidence is encouraging but highlights a critical need for standardised formulations and consistent reporting; practitioners should remain cognisant that protocols vary considerably between facilities, and long-term efficacy data are still emerging.
Read the full abstract on PubMed
Practical Takeaways
- •PRP demonstrates therapeutic potential for tendon/ligament injuries with good safety profile, but ensure your provider uses a standardized, documented preparation method since current variation limits predictability
- •Consider combination therapy with stem cells if available, but recognize this approach still needs more rigorous clinical validation before becoming standard practice
- •Request detailed information about your PRP's platelet concentration, leukocyte levels, and activation method—these variables significantly impact outcomes but are inconsistently reported
Key Findings
- •Systematic review of 22 studies found PRP improves lameness, tissue healing, and return-to-competition rates in equine tendon and ligament injuries
- •Significant variability exists in PRP preparation methods including platelet/leukocyte concentrations, activation techniques, and dosing protocols
- •Combination of PRP with mesenchymal stem cells may enhance outcomes but requires further controlled investigation
- •Lack of standardized PRP production and reporting protocols limits reproducibility and clinical guideline development