Rethinking equine gastric ulcer syndrome: Part 3 – Equine glandular gastric ulcer syndrome (EGGUS)
Authors: Sykes B., Jokisalo J. M.
Journal: Equine Veterinary Education
Summary
# Editorial Summary: Equine Glandular Gastric Ulcer Syndrome Whilst squamous gastric ulceration has dominated clinical discussion for decades, emerging evidence demonstrates that ulceration of the glandular (fundic) mucosa represents a distinct pathophysiological entity requiring separate consideration in equine gastric disease. This review synthesises current knowledge on glandular gastric ulceration, examining the mechanisms underlying mucosal damage, associated risk factors and prevalence data to help practitioners differentiate between the two primary forms of equine gastric ulcer syndrome. Key distinctions include differences in acid production, protective mucus layers and the microbial environment between squamous and glandular regions, which substantially influence how lesions develop and respond to intervention. The authors detail evidence-based approaches to treatment and prevention specific to glandular disease, moving beyond the acid-suppression strategies that dominate squamous ulcer management. Understanding these mechanistic differences is essential for farriers, veterinarians and equine support professionals involved in performance horse management, as misdiagnosis or inappropriate treatment protocols may prolong recovery and compromise welfare in affected animals.
Read the full abstract on the publisher's site
Practical Takeaways
- •Recognize that glandular gastric ulcers are a distinct condition requiring different diagnostic and treatment approaches than squamous ulcers
- •Understand specific risk factors for EGGUS to implement targeted prevention strategies in your management protocols
- •Apply evidence-based treatment recommendations specific to glandular ulceration rather than using generic gastric ulcer protocols
Key Findings
- •Significant pathophysiological differences exist between squamous and glandular gastric ulceration in horses
- •Glandular gastric ulcers have distinct risk factors and prevalence patterns compared to squamous ulcers
- •Treatment and prevention strategies for EGGUS differ from those for squamous gastric ulcers