Non-steroidal anti-inflammatory drugs in equine orthopaedics.
Authors: Jacobs Carrie C, Schnabel Lauren V, McIlwraith C Wayne, Blikslager Anthony T
Journal: Equine veterinary journal
Summary
# Editorial Summary Orthopaedic conditions represent a substantial proportion of equine veterinary caseloads, with NSAIDs forming the cornerstone of inflammatory management across soft tissue and bony injuries. Jacobs and colleagues conducted a comprehensive literature review synthesising current evidence on NSAID efficacy, mechanisms of action on both healthy and inflamed musculoskeletal tissues, and associated adverse effects, whilst evaluating emerging therapeutic approaches to inflammation control in equine orthopaedics. The review distinguishes between non-selective inhibitors (affecting both COX-1 and COX-2 pathways) and selective COX-2 inhibitors, highlighting how this pharmacological distinction influences both therapeutic benefit and gastrointestinal safety profiles in clinical practice. Understanding these nuances—particularly regarding dose optimisation, duration of use, and tissue-specific effects—enables practitioners to make evidence-informed decisions when selecting NSAID protocols for individual cases and to recognise when alternative or adjunctive anti-inflammatory strategies may be warranted. For equine professionals managing musculoskeletal injuries, this synthesis of current literature provides essential context for contextualising NSAID use within broader rehabilitation strategies and for anticipating developments in inflammation management beyond traditional anti-inflammatory pharmacology.
Read the full abstract on PubMed
Practical Takeaways
- •NSAIDs remain a cornerstone of orthopaedic management in horses; choice between selective and non-selective agents should be based on individual case needs and contraindications
- •Understanding NSAID effects on both normal and inflamed tissues helps optimize treatment protocols and minimize adverse effects in your patients
- •Stay informed about emerging anti-inflammatory strategies as new options may complement or enhance traditional NSAID therapy for orthopaedic cases
Key Findings
- •NSAIDs are fundamental to managing equine orthopaedic disorders with multiple selective and non-selective agents available
- •Extensive literature documents efficacy of NSAIDs on inflamed musculoskeletal tissues and their side effect profiles
- •Review identifies emerging and future therapeutic avenues for inflammation management in equine orthopaedics beyond traditional NSAIDs