Plasma concentrations of inflammatory markers in previously laminitic ponies.
Authors: Wray, Elliott, Bailey, Harris, Menzies-Gow
Journal: Equine veterinary journal
Summary
# Plasma inflammatory markers in previously laminitic ponies Understanding why certain ponies develop recurrent laminitis whilst others remain unaffected requires investigation of their underlying inflammatory profiles. Wray and colleagues compared plasma concentrations of ten inflammatory markers and metabolic indicators in 38–42 previously laminitic ponies against 39–41 control animals, sampling both in late spring and winter to capture seasonal variation. Most markers showed no difference between laminitic and non-laminitic groups; however, adiponectin—a protective, anti-inflammatory hormone—was significantly reduced in previously laminitic ponies (median 2.1 μg/l versus 3.4 μg/l in controls), suggesting compromised anti-inflammatory capacity rather than excessive inflammation. Triglyceride concentrations were also slightly elevated in the laminitis-prone group, whilst season, sex and bodyweight emerged as important variables affecting fibrinogen, serum amyloid A, haptoglobin and interleukin-4 concentrations. These findings propose that recurrent laminitis susceptibility may reflect a deficiency in protective inflammatory mechanisms rather than a hyperinflammatory state. For practitioners, this reframes the clinical picture: previously affected ponies may lack adequate metabolic "brakes" on inflammation, suggesting that management strategies strengthening systemic anti-inflammatory capacity—through careful nutrition, weight management and appropriate exercise—could be as critical as reducing inflammatory triggers. The reduced adiponectin also hints at insulin dysregulation and metabolic dysfunction as underlying predisposing factors worthy of targeted assessment and intervention.
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Practical Takeaways
- •Previously laminitic ponies show reduced anti-inflammatory capacity (low adiponectin) rather than high inflammation, suggesting management should focus on supporting anti-inflammatory pathways rather than suppressing inflammation
- •Seasonal variation in inflammatory markers is substantial, with winter showing higher fibrinogen, serum amyloid A, haptoglobin, and interleukin-4; this may inform timing of pasture management for at-risk animals
- •Elevated triglycerides in previously laminitic ponies align with metabolic predisposition; monitoring metabolic status and weight management remain important preventive strategies
Key Findings
- •Adiponectin concentrations were significantly lower in previously laminitic ponies (2.1 μg/l) compared to control ponies (3.4 μg/l; P<0.0001)
- •Plasma triglyceride concentration was significantly higher in previously laminitic animals (0.5 mmol/l) than controls (0.4 mmol/l; P=0.02)
- •Season, gender, and bodyweight significantly influenced multiple inflammatory markers (fibrinogen, serum amyloid A, haptoglobin, interleukin-4), but laminitis status only influenced adiponectin
- •Recurrent laminitis may be associated with reduced anti-inflammatory capacity rather than elevated proinflammatory markers