Summary

# Editorial Summary Repeat breeding in mares represents a significant fertility challenge, often linked to inadequate endometrial development or compromised uterine environment rather than ovulatory dysfunction. Ahmed and colleagues investigated whether intrauterine infusion of platelet-rich plasma (PRP) or lyophilised equine growth factors (L-GFequina) could enhance reproductive outcomes in 73 purebred Arabian mares with a history of three successive breeding failures, comparing treated animals against untreated controls using standardised protocols of 20 mL administered on day two post-oestrus. Neither intervention altered preovulatory follicle diameter in the subsequent cycle; however, both PRP and L-GFequina significantly increased endometrial thickness compared to controls, shortened oestrous cycle length, and—most notably—improved pregnancy rates in treated groups. These findings suggest that growth factor supplementation addresses a fundamental aspect of repeat breeder syndrome by promoting endometrial proliferation, potentially restoring the physiological conditions necessary for embryonic establishment. For practitioners managing repeat breeders, particularly in Arabian bloodlines prone to this condition, intrauterine growth factor therapy represents a targeted, evidence-based intervention worth considering before pursuing more invasive diagnostic or surgical approaches, though the specific pregnancy rate figures and long-term outcomes warrant careful review of the complete publication.

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Key Findings

• •Intrauterine PRP and L-GFequina infusion significantly increased endometrial thickness compared to control group
• •Both PRP and L-GFequina treatments shortened estrus cycle length in treated mares
• •Higher pregnancy rates were recorded in L-GFequina and PRP treated groups versus control
• •No significant difference in preovulatory follicle diameter between control and treated groups in post-treatment cycle

Conditions Studied

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