A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey.
Authors: Wang Tianqi, Shi Xiaoyuan, Liu Ziwen, Ren Wei, Wang Xinrui, Huang Bingjian, Kou Xiyan, Liang Huili, Wang Changfa, Chai Wenqiong
Journal: Animals : an open access journal from MDPI
Summary
Researchers investigating the Dezhou donkey breed identified a previously unknown genetic variant (A > G polymorphism) in intron 1 of the LCORL gene using targeted sequencing technology, building on established evidence linking this gene to body size traits in horses and pigs. The analysis of 112 donkeys revealed that animals carrying the GG genotype were significantly larger across multiple measurements—including body height, body length and chest circumference—and produced heavier hides (p < 0.05) compared with those homozygous for the AA variant. This SNP at position g.112558859 could serve as a useful genomic marker for selecting breeding stock with improved frame size and hide yield, traits of considerable economic importance in commercial donkey production. For breeding programmes and stud book management, genotyping at this locus offers a practical tool to identify animals with genetic potential for growth and hide development without waiting for phenotypic assessment. Further validation across different donkey populations and investigation of the mechanism behind this association would strengthen its application in selective breeding strategies.
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Practical Takeaways
- •This genetic marker could be incorporated into breeding programs for Dezhou donkeys to selectively breed for larger frame size and improved hide yield
- •Genetic testing for the GG genotype may help identify donkeys with superior growth potential early in development
- •Applicable primarily to donkey production systems focused on hide quality and body size traits rather than riding or working performance
Key Findings
- •A novel A > G SNP (g.112558859) was identified in intron 1 of the LCORL gene in Dezhou donkeys
- •Individuals with GG genotype had significantly higher body height, body length, chest circumference and hide weight compared to AA genotype (p < 0.05)
- •The g.112558859 A > G locus can serve as a potential candidate marker for selecting donkeys with larger body size and higher hide yield