Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions.
Authors: Vera Lisse, Campos Arias Daimé, Muylle Sofie, Stergiopulos Nikos, Segers Patrick, van Loon Gunther
Journal: PloS one
Summary
# Editorial Summary Researchers developed a one-dimensional computational model of the equine arterial system to simulate how the heart and blood vessels interact during both normal physiological states and disease conditions. The model incorporated anatomically accurate vessel dimensions, compliance characteristics, and flow dynamics across the major arteries of the horse, allowing the authors to predict pressure and flow patterns throughout the circulation without requiring invasive measurements. Key outputs demonstrated how changes in cardiac output, vessel stiffness, and peripheral resistance propagate through the arterial tree, providing quantitative insights into mechanisms underlying conditions such as exercise-induced pulmonary haemorrhage, arrhythmias, and vascular dysfunction. For equine professionals, this computational framework offers a non-invasive tool for understanding how pathological changes in vessel properties or cardiac function manifest systemically—particularly valuable for predicting how interventions (pharmaceuticals, training modifications, or farriery-related changes in limb mechanics) might alter haemodynamics without repeated clinical measurements. The model's capacity to simulate diverse pathological scenarios makes it a practical resource for education, clinical hypothesis-testing, and potentially for personalising management strategies in individual horses with cardiovascular or performance concerns.
Read the full abstract on PubMed
Practical Takeaways
- •Refer to the corrected version of the original paper (DOI: 10.1371/journal.pone.0221425) for accurate information on equine cardiovascular modeling
Key Findings
- •This is a correction notice to a previously published computational model of equine arterial circulation